Assessment of dermal exposure and histopathologic changes of different sized nano-silver in healthy adult rabbits

نویسندگان

  • Mohammad kazem Koohi
  • Marzie Hejazy
  • Farzad Asadi
  • Lisa Bregoli
  • Federico Benetti
  • Marco Venturini
  • Pengpeng Liu
  • Rongfa Guan
  • Yoon-Hee Park
  • Sang Hoon Jeong
  • Sang Min Yi
  • Byeong Hyeok Choi
  • Yu-Ri Kim
  • In-Kyoung Kim
  • Meyoung-Kon Kim
  • Sang Wook Son
چکیده

The human skin equivalent model (HSEM) is well known as an attractive alternative model for evaluation of dermal toxicity. However, only limited data are available on the usefulness of an HSEM for nanotoxicity testing. This study was designed to investigate cutaneous toxicity of polystyrene and TiO2 nanoparticles using cultured keratinocytes, an HSEM, and an animal model. In addition, we also evaluated the skin sensitization potential of nanoparticles using a local lymph node assay with incorporation of BrdU. Findings from the present study indicate that polystyrene and TiO2 nanoparticles do not induce phototoxicity, acute cutaneous irritation, or skin sensitization. Results from evaluation of the HSEMs correspond well with those from animal models. Our findings suggest that the HSEM might be a useful alternative model for evaluation of dermal nanotoxicity.

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تاریخ انتشار 2011